Information

Books

W. Zhang and I. Shmulevich, Eds. Computational And Statistical Approaches To Genomics, Kluwer Academic Publishers, Boston, 2002.

W. Zhang, I. Shmulevich, J. Astola. Microarray Quality Control, John Wiley and Sons, March 2004.

E. R. Dougherty, I. Shmulevich, J. Chen, Z. J. Wang, Eds. Genomic Signal Processing and Statistics, Hindawi Publishing Corporation, 2005.

W. Zhang and I. Shmulevich, Eds. Computational And Statistical Approaches To Genomics, 2nd Edition, Springer, 2006.

I. Shmulevich and E. R. Dougherty. Genomic Signal Processing, Princeton University Press, 2007.

I. Shmulevich and E. R. Dougherty. Probabilistic Boolean Networks as Models of Gene Regulatory Networks, SIAM Press (in preparation).

Journals – Computational Biology and Genomics (by year)

2008

W. Liu, H. Lähdesmäki, E. R. Dougherty, I. Shmulevich, "Inference of Boolean Networks using Sensitivity Regularization" (submitted).

H. Lähdesmäki, I. Shmulevich, “Learning the Structure of Dynamic Bayesian Networks from Time Series and Steady State Measurements," (submitted).

D. J. Galas, M. Nykter, G. W. Carter, N. D. Price, I. Shmulevich, "Set-based complexity and biological information," (submitted).

M. Korb, A. G. Rust, V. Thorsson, C. Battail, B. Li, D. Hwang, K. Kennedy, J. C. Roach, C. M. Rosenberger, M. Gilchrist, D. Zak, C. Johnson, B. Marzolf, A. Aderem, I. Shmulevich, H. Bolouri, "The Innate Immune Database (IIDB)," BMC Immunology (submitted).

H. Lähdesmäki, A. G. Rust, I. Shmulevich, "Probabilistic inference of transcription factor binding from multiple data sources," PLoS ONE (in press).

S. A. Ramsey, S. L. Klemm, D. E. Zak, K. A. Kennedy, V. Thorsson, B. Li, M. Gilchrist, E. Gold, C. D. Johnson, V. Litvak, G. Navarro, J. C. Roach, C. M. Rosenberger, A. G. Rust, N. Yudkovsky, A. Aderem, I. Shmulevich, "Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics," PLoS Computational Biology (in press).

M. Nykter, N. D. Price, A. Larjo, T. Aho, S. A. Kauffman, O. Yli-Harja, I. Shmulevich, "Critical networks exhibit maximal information diversity in structure-dynamics relationships," Physical Review Letters (in press).

M. Nykter, N. D. Price , M. Aldana, S. A. Ramsey, S. A. Kauffman, L. Hood, O. Yli-Harja, I. Shmulevich, "Gene Expression Dynamics in the Macrophage Exhibit Criticality," Proceedings of the National Academy of Sciences of the USA, Vol. 105, No. 6, pp. 1897-1900, 2008.

2007

J. Selinummi, A. Niemistö, R. Saleem, G. W. Carter, J. Aitchison, O. Yli-Harja, I. Shmulevich, and J. Boyle, "A Case Study on 3-D Reconstruction and Shape Description of Peroxisomes in Yeast, " IEEE International Conference on Signal Processing and Communication (ICSPC07), Dubai, United Arab Emirates (UAE), November 24-27, 2007.

A. Niemistö, T. Korpelainen, R. Saleem, O. Yli-Harja, J. Aitchison, I. Shmulevich, "A K-Means Segmentation Method for Finding 2-D Object Areas Based on 3-D Image Stacks Obtained by Confocal Microscopy," 29th International Conference of the IEEE Engineering in Medicine and Biology Society, Lyon, France, August 23-26, 2007.

H. Lähdesmäki, I. Shmulevich, "Probabilistic framework for transcription factor binding prediction," IEEE International Workshop on Genomic Signal Processing and Statistics, Tuusula, Finland, June 10-12, 2007.

S. A. Kauffman, R. K. Logan, R. Este, R. Goebel, D. Hobill, I. Shmulevich, "Propagating Organization: An Enquiry," Biology and Philosophy, Vol. 23, No. 1, pp. 27-45, 2007.

R. Vêncio, I. Shmulevich, "ProbCD: enrichment analysis accounting for categorization uncertainty," BMC Bioinformatics, Vol. 8, No. 383, 2007.

P. Krawitz, I. Shmulevich, "Entropy of complex relevant components in Boolean networks," Physical Review E, Vol. 76, 036115, 2007.

N. D. Price, I. Shmulevich, "Biochemical and statistical network models for systems biology," Current Opinion in Biotechnology, Vol. 18, pp. 365-370, 2007.

R. Vêncio, L. Varuzza, C. Pereira, H. Brentani, I. Shmulevich, "Simcluster: clustering enumeration gene expression data on the simplex space," BMC Bioinformatics, Vol. 8, No. 246, 2007.

M. Ahdesmäki , H. Lähdesmäki, A. Gracey , I. Shmulevich and O. Yli-Harja, "Robust regression for periodicity detection in non-uniformly sampled time-course gene expression data," BMC Bioinformatics, Vol. 8, No. 233, 2007.

P. Krawitz, I. Shmulevich, "Basin Entropy in Boolean Network Ensembles," Physical Review Letters, Vol. 98, No. 15, pp. 158701, 2007.

N. D. Price, J. Trent, A. K. El-Naggar, D. Cogdell, E. Taylor, K. K. Hunt, R. E. Pollock, L. Hood, I. Shmulevich, W. Zhang, “Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas,” Proceedings of the National Academy of Sciences of the USA, Vol. 104, No. 9, pp- 3414-3419, 2007.

2006

A. Niemistö, J. Selinummi, R. Saleem, I. Shmulevich, J. Aitchison, O. Yli-Harja, "Extraction of the number of peroxisomes in yeast cells by automated image analysis," The 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, New York, New York, August 30 - September 3, 2006.

C. Gershenson, S. A. Kauffman, and I. Shmulevich, "The Role of Redundancy in the Robustness of Random Boolean Networks," in Rocha, L. M., L. S. Yaeger, M. A. Bedau, D. Floreano, R. L. Goldstone, and A. Vespignani (Eds.), Artificial Life X, Proceedings of the Tenth International Conference on the Simulation and Synthesis of Living Systems, pp. 35-42. MIT Press, 2006.

H. Lähdesmäki, S. Hautaniemi, I. Shmulevich, O. Yli-Harja, "Relationships Between Probabilistic Boolean Networks and Dynamic Bayesian Networks as Models of Gene Regulatory Networks" Signal Processing, Vol. 86, No. 4, pp. 814-834, 2006.

M. Nykter, K. K. Hunt, R. E. Pollock, A. K. El-Naggar, E. Taylor, I. Shmulevich, O. Yli-Harja, W. Zhang, “Unsupervised analysis uncovers changes in histopathologic diagnosis in supervised genomic studies,” Technology in Cancer Research and Treatment, Vol. 5, No. 2, pp. 177-182, 2006.

R. Jiang, C. Mircean, I. Shmulevich, D. Cogdell, Y. Jia, I. Tabus, K. Aldape, R. Sawaya, J. M. Bruner, G. N. Fuller, W. Zhang, “Pathway alterations during glioma progression revealed by reverse phase protein lysate arrays,” Proteomics, Vol. 6, pp. 2964-2971, 2006. [over picture]

I. Tabus, A. Hategan, C. Mircean, J. Rissanen, I. Shmulevich, W. Zhang, J. Astola, “Nonlinear modeling of protein expressions in protein arrays,” IEEE Transactions on Signal Processing, Vol. 54, No. 6, pp. 2394-2407, 2006.

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2005

A. Niemistö, I. Shmulevich, O. Yli-Harja, L. Chirieac, S. R. Hamilton, “Automated Quantification of Lymph Node Size and Number in Surgical Specimens of Stage II Colorectal Cancer,” 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Shanghai, China, September 1-4, 2005, pp. 6313 - 6316.

M. Nykter, O. Yli-Harja, I. Shmulevich, "Normalized compression distance for gene expression analysis" Workshop on Genomic Signal Processing and Statistics (GENSIPS), Newport, RI, May 22-25, 2005.

I. Tabus, A. Hategan, C. Mircean, I. Shmulevich, W. Zhang, J. Astola, "Nonlinear modeling of protein expression ratios in lysate array technology" Workshop on Genomic Signal Processing and Statistics (GENSIPS), Newport, RI, May 22-25, 2005.

H. Lähdesmäki, O. Yli-Harja, W. Zhang, I. Shmulevich, "Intrinsic dimensionality in gene expression analysis" Workshop on Genomic Signal Processing and Statistics (GENSIPS), Newport, RI, May 22-25, 2005.

A. Niemistö, V. Dunmire, O. Yli-Harja, W. Zhang, I. Shmulevich, "Analysis of angiogenesis using in vitro experiments and stochastic growth models," Physical Review E, Vol. 72, 062902, 2005.

T. Toulouse, P. Ao, I. Shmulevich, S. A. Kauffman, “Noise in a Small Genetic Circuit that Undergoes Bifurcation,” Complexity, Vol. 11, No. 1, pp. 45-51, 2005.

I. Shmulevich, S. A. Kauffman, M. Aldana, "Eukaryotic cells are dynamically ordered or critical but not chaotic" Proceedings of the National Academy of Sciences of the USA, Vol. 102, No. 38, pp. 13439-13444, 2005.

M. Brun, E. R. Dougherty, I. Shmulevich, “Steady-State Probabilities for Attractors in Probabilistic Boolean Networks,” Signal Processing, Vol. 85, No. 4, pp. 1993-2013, 2005.

I. Shmulevich, "The prospect of systems biology for toxicology," Igaku no Ayumi (Journal of Clinical and Experimental Medicine), Vol. 213, No. 4, pp. 269-272, 2005 (in Japanese).

E. Lee, C. Mircean, I. Shmulevich, H. Wang, J. Liu, A. Niemistö, J. Kavanagh, JH Lee, W. Zhang, "Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion" Molecular Cancer, Feb 02;4(1):7, 2005.

A. Niemistö, V. Dunmire, O. Yli-Harja, W. Zhang, I. Shmulevich, "Robust quantification of in vitro angiogenesis through image analysis," IEEE Transactions on Medical Imaging, Vol. 24, No. 4, pp. 549-553, 2005.

C. Mircean, I. Shmulevich, D. Cogdell, W. Choi, Y. Jia, I. Tabus, S. R. Hamilton, W. Zhang, "Robust estimation of protein expression ratios with lysate microarray technology," Bioinformatics, Vol. 21, No. 9, pp. 1935-1942, 2005.

H. Lähdesmäki, I. Shmulevich, V. Dunmire, O. Yli-Harja, W. Zhang, "In Silico Microdissection of Microarray Data from Heterogeneous Cell Populations," BMC Bioinformatics 6:54, 2005.

G. N. Fuller, C. Mircean, I. Tabus, E. Taylor, R. Sawaya, J. M. Bruner, I. Shmulevich, W. Zhang, "Molecular voting for glioma classification reflecting heterogeneity in the continuum of cancer progression," Oncology Reports, Vol. 14, pp. 651-656, 2005.

2004

A. Niemistö, L. Hu, O. Yli-Harja, W. Zhang, I. Shmulevich, "Quantification of in vitro cell invasion through image analysis," in Proceedings of the 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS'04), San Francisco, California, USA, Sep. 1-5, 2004, pp. 1703-1706.

C. Mircean, I. Tabus, J. Astola, T. Kobayashi, H. Shiku, M. Yamaguchi, I. Shmulevich, W. Zhang, "Quantization and similarity measure selection for discrimination of lymphoma subtypes under k-nearest neighbor classification," Proceedings of SPIE Photonics West, Biomedical Optics, San Jose, CA, Jan. 24-29, 2004.

I. Shmulevich, S. A. Kauffman, "Activities and Sensitivities in Boolean Network Models," Physical Review Letters, Vol. 93, No. 4, pp. 048701(1-4), 2004. [Supplementary material available here]

I. Shmulevich, "Book review: Guide to analysis of DNA microarray data, second edition," Bulletin of Mathematical Biology, Vol. 66, pp. 1939-1942, 2004.

R. F. Hashimoto, S. Kim, I. Shmulevich, W. Zhang, M. L. Bittner, E. R. Dougherty, "Growing genetic regulatory networks from seed genes," Bioinformatics, Vol. 20, No. 8, pp. 1241-1247, 2004.

E. R. Dougherty, I. Shmulevich, M. L. Bittner, "Genomic Signal Processing: The Salient Issues," EURASIP Journal on Applied Signal Processing, Vol. 2004, No. 1, pp. 146-153, 2004.

H. Lähdesmäki, X. Hao, B. Sun, L. Hu, O. Yli-Harja, I. Shmulevich, and W. Zhang, "Distinguishing key biological pathways between primary breast cancers and their lymph node metastases by gene function-based clustering analysis," International Journal of Oncology, Vol. 24, No. 6, pp. 1589–1596, June 2004.

X. Hao, B. Sun, L. Hu, H. Lähdesmäki, V. Dunmire, Y. Feng, S.-W. Zhang, H. Wang, C. Wu, H. Wang, G. N. Fuller, W. F. Symmans, I. Shmulevich, and W. Zhang, "Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis," Cancer, Vol. 100, No. 6, pp. 1110-1122, 2004.

C. Mircean, I. Tabus, T. Kobayashi, M. Yamaguchi, H. Shiku, I. Shmulevich, W. Zhang, "Pathway Analysis of Informative Genes from Microarray Data Reveals that Metabolism and Signal Transduction Genes Distinguish Different Subtypes of Lymphomas," International Journal of Oncology, Vol. 24, No. 3, pp. 497-504, 2004.

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2003

I. Shmulevich, H. Lähdesmäki, E. R. Dougherty, J. Astola, W. Zhang, "The role of certain Post classes in Boolean network models of genetic networks," Proceedings of the National Academy of Sciences of the USA, Vol. 100, No. 19, pp. 10734-10739, 2003.

I. Shmulevich, I. Gluhovsky, R. Hashimoto, E. R. Dougherty, and W. Zhang, "Steady-State Analysis of Genetic Regulatory Networks Modeled by Probabilistic Boolean Networks," Comparative and Functional Genomics, Vol. 4, No. 6, pp. 601-608, 2003. [Supplementary material available here]

I. Shmulevich, "Model Selection in Genomics," Guest Editorial in Toxicogenomics Section of Environmental Health Perspectives, Vol. 111, No. 6, May 2003, pp. A328-A329.

I. Shmulevich, J. Astola, D. Cogdell, S. R. Hamilton, and W. Zhang, "Data Extraction From Composite Oligonucleotide Microarrays," Nucleic Acids Research, Vol. 31, No. 7, e36, 2003.

E. R. Dougherty and I. Shmulevich, "Mappings Between Probabilistic Boolean Networks," Signal Processing, Vol. 83, No. 4, pp. 799-809, 2003.

H. Lähdesmäki, I. Shmulevich, and O. Yli-Harja, "On Learning Gene Regulatory Networks Under the Boolean Network Model," Machine Learning, Vol. 52, pp. 147-167, 2003.

J. Morikawa, H. Li, S. Kim, K. Nishi, S. Ueno, E. Suh, E. Dougherty, I. Shmulevich, H. Shiku, W. Zhang, and T. Kobayashi, "Identification of signature genes by microarray for acute myeloid leukemia without maturation and acute promyelocytic leukemia with t(15;17)(q22;q12)(PML/RARa)," International Journal of Oncology, Vol. 23, No. 3, pp. 617-625, 2003.

T. Kobayashi, M. Yamaguchi, S. Kim, J. Morikawa, S. Ogawa, S. Ueno, E. Suh, E. Dougherty, I. Shmulevich, H. Shiku, W. Zhang, "Microarray Reveals Differences in Both Tumors and Vascular Specific Gene Expression in De Novo CD5+ and CD5- Diffuse Large B-cell Lymphomas," Cancer Research, vol. 63, pp. 60-66, January 2003.

2002

I. Shmulevich, E.R. Dougherty, and W. Zhang, "From Boolean to probabilistic Boolean networks as models of genetic regulatory networks,'' Proceedings of the IEEE, Vol. 90, No. 11, pp. 1778-1792, 2002.

I. Shmulevich, E. R. Dougherty, W. Zhang, "Gene Perturbation and Intervention in Probabilistic Boolean Networks," Bioinformatics, Vol. 18, No. 10, pp. 1319-1331, 2002.

I. Shmulevich, E.R. Dougherty, and W. Zhang, "Control of stationary behavior in Probabilistic Boolean Networks by means of structural intervention," Journal of Biological Systems, Vol. 10, No. 4, pp. 431-445, 2002.

I. Shmulevich, W. Zhang, "Binary Analysis and Optimization-Based Normalization of Gene Expression Data," Bioinformatics, Vol. 18, No. 4, pp. 555-565, 2002.

I. Shmulevich, E. R. Dougherty, S. Kim, W. Zhang, "Probabilistic Boolean Networks: A Rule-based Uncertainty Model for Gene Regulatory Networks," Bioinformatics, Vol. 18, No. 2, pp. 261-274, 2002.

S. Kim, E. R. Dougherty, I. Shmulevich, K. R. Hess, S. R. Hamilton, J. M. Trent, G. N. Fuller, W. Zhang, "Identification of Combination Gene Sets for Glioma Classification," Molecular Cancer Therapeutics, vol. 1, pp. 1229-1236, November 2002.

I. Shmulevich, K. Hunt, A. El-Naggar, E. Taylor, L. Ramdas, P. Labordé, K. R. Hess, R. Pollock, W. Zhang, "Tumor Specific Gene Expression Profiles in Human Leiomyosarcoma: an Evaluation of Intra-Tumor Heterogeneity," Cancer, Vol. 94, No. 7, pp. 2069-2075, 2002.

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